Endocrine Abstracts

Replacement mineralocorticoid(MC)therapy in patients with primary hypoadrenalism is titrated according to clinical and /or biochemical criteria. No single objective assessment is adequate for monitoring,though targets for plasma renin and serum electrolyte concentrations and blood pressure(BP)have been proposed.Plasma renin concentrations within the middle to upper normal range would suggest adequate MC replacement. We reviewed the case notes of 18 patients in order to identif...

Background and aims: Maternal subclinical hypothyroidism during early pregnancy has been shown to be associated with impaired neuropsyhological developement of children.Recent consensus guidelines have recmmended aggressive case finding for thyroid or other autoimmune disorders.We have examined the efficacy of these criteria in identifying women with thyroid dysfunction during early pregnancy.Subjects and methods:During july 2002 to june 2003,we propecti...

Soy phytoestrogens (PE) have been shown to improve insulin resistance and lipids but may adversely affect thyroid function.Objective: To determine the effects of soy PE on thyroid function, insulin resistance and lipid parameters in patients with subclinical hypothyroidism.Design: A randomised, double-blind, crossover study was undertaken involving 60 patients with subclinical hypothyroidism. Patients were randomly assigned to eith...